INTERNATIONAL 8th USBİLİM HEALTH, ENGINEERING AND APPLIED SCIENCES CONGRESS
HOW ALKALOIDS FROM MEDICINAL PLANTS HELP MANAGE DIABETES MELLITUS
Yayıncı:
Akademik Paylaşım Platformu Publishing House - APP Publications
Because of their abundant supply of bioactive phytochemicals, medicinal plants play an essential role in the health industry by managing many infectious illnesses. Worldwide, millions of people lose their lives each year to diabetes mellitus, a chronic metabolic illness whose prevalence is steadily rising. The insulin deficit caused by β-cell death characterizes type 1 diabetes, whereas insulin resistance and β-cell dysfunction describe the most common form, type 2 diabetes. Regulating glucose homeostasis and combating the development of late-diabetic problems have led to the creation of many kinds of synthetic medicines. Unfortunately, the effectiveness and safety of some of these chemical agents are questionable. The biological effects of alkaloids, which include antidiabetic characteristics, have been extensively studied and documented. There has been a lot of interest in these compounds as promising therapeutic development prospects since their chemical structures may interact with several proteins that are involved in glucose regulation. This study aims to explore the potential of plant alkaloids as anti-diabetic agents. Current study typically suggest alkaloids as strong α-glucosidase inhibitors, but there is insufficient clinical evidence for these phytochemicals to be able to follow their fingerprint in humans. Other substances, with the exception of some groups of monoterpene alkaloids, exhibited comparable characteristics, as did the already known anti-diabetic medications, including amino sugars and other pertinent medications. Additionally, additional in vitro and in vivo research are required to confirm these results; yet, plant based alkaloids show promise as alternative additives for diabetes mellitus therapy.
