Nöroloji Ders Kitabı II: Sinir Sistemi Hastalıkları ve Tedavi
Lewy Body Dementia and Parkinson’s Disease Dementia
Yazarlar:
Eser BULUŞ
Gökhan ERKOL
Yayıncı:
İstanbul Üniversitesi–Cerrahpaşa Üniversite Yayınevi
Lewy Body Dementia (LCD) is the second most common type of neurodegenerative dementia after Alzheimer's disease. It belongs to the group of α-synucleinopathies. It mostly occurs sporadically. It is characterized by a tetrad of visual hallucinations, fluctuating cognitive functions and progressive decline, parkinsonism features, and REM sleep behavior disorder. Neuropsychiatric symptoms are the most common initial manifestation of LCD disease and are seen in 90% of cases. Fluctuations in alertness, tendency to sleep, prolonged daytime napping, episodes of staring, and complex speech patterns distinguish LCD from other dementias. Recurrent falls, syncope, transient loss of consciousness, sensitivity to neuroleptics, and systemic delusions support the diagnosis of LCD. Parkinson's Disease Dementia is a type of dementia that occurs during the course of Parkinson's disease, with a behavioral and cognitive profile consistent with Parkinson's disease (PD). Acetylcholinesterase inhibitors are used in the treatment of cognitive dysfunction in both PD dementia and LCD.