CURRENT TRENDS IN NEUROSCIENCES
EXPERIMENTAL AND CLINICAL APPROACH TO SCHIZOPHRENIA AND BIPOLAR DISORDER
Yayıncı:
İstanbul Üniversitesi Yayınları
Schizophrenia, a chronic illness, causes psychosis, leading to detachment from reality through positive and negative symptoms and dysfunction in emotion and cognition. Bipolar disorder is a common psychiatric disorder characterized by chronic mood episodes that cause significant psychosocial impairment and functional decline. Both psychiatric disorders have a chronic course and cause severe disability. Neurotransmitter hypotheses have been emphasized in studies of their etiology. Various genetic, neuroimaging, and neuroimmunology studies have been carried out. At the same time, animal studies play an important role in the study of these two diseases. To this end, the neurotransmitter systems involved in the neurobiology and etiology of both schizophrenia and bipolar disorder will be reviewed and the animal models developed will be presented. Animal models of schizophrenia will be evaluated under three main headings: developmental models, drug-induced models, and genetic models. Animal models of bipolar disorder will be divided into four categories; pharmacological, nutritional, environmental, and genetic models in manic episode and it will be divided into three categories; environmental, biological, and genetic models in depressive episode. The aim is to present the hypotheses on the etiology of schizophrenia and bipolar disorder, whose psychopathology has not yet been fully elucidated, in the light of the data obtained to date, and to describe the animal models developed in this context
