3. International Ankara Conference On Scientific Research The Book Of Full Texts (applied Sciences)
Bellekle İlgi̇li̇ Genleri̇n Bi̇yoi̇nformati̇k Anali̇zi̇ İle Bi̇yoloji̇k Yolaklar Ve Etki̇leşi̇mleri̇n İncelenmesi̇
Disiplin:
Cell Biology,Gene Expression
Konu:
Cell Biology,Gene Expression
Parallel with the recent advancements on technology-dependent techniques, memory, which is an important part of cognition, has been studied intensively. Memory has a multi-layered structure that comprises behavioral level on one side and molecular level on the other side. Aside from this multilayered structure, researchers should consider miscellaneous processes that constitute the memory, namely, encoding, storage, retrieval etc. as well. Due to its aforementioned properties, memory is a challenging biological storage unit, which is in the center of a wide variety of disciplines and approaches. This study used a systems biology approach and aimed at the identification of transcription factors, protein interactions, signaling pathways and diseases associated with memory. In this study, previously identified memoryrelated gene list was enriched in order to put forth interconnectivities between memory and biological pathways and interactions. A total of 1010 upregulated and 522 downregulated genes were enriched with bioinformatics tools. 13 different gene set libraries such as transcription factors, protein interactions, signaling pathways, disease associations and Gene Ontology Terms were used in the analysis. Results indicated that Wnt signaling pathway -particularly canonical Wnt/β-catenin pathway-, circadian rhythm mechanism, and epigenetic mechanisms were associated with memory. CTNNB1, STAT3 and ESR1 were some of the memory related transcription factors. The memory gene list was significantly enriched with Gene Ontology terms such as ligand-gated ion channel activity, rRNA binding, and translation initiation factor activity for molecular function; synaptic signaling for biological process and synapse, axon, and neuron projection for cellular component. These results support the theories of molecular mechanism of memory. One unanticipated finding was that memory genes are associated with some types of cancers, eye disorders and hematocyte related disorders. The association with eye disorders can justify the relationship between visual perception and memory. Moreover, taste transduction, another associated signaling pathway, confirms the relationship between taste and memory. This study ANKARA INTERNATIONAL CONGRESS ON SCIENTIFIC RESEARCH -III OCTOBER 2-4, 2020 ANKARA-TURKEY THE BOOK OF FULL TEXTS (APPLIED SCIENCES) WEB: https://www.ankarakongresi.org/ E-MAIL: inimasorg@gmail.com 257 has important implications for using new methods for integrating data and employing different tools in memory researches. To develop a full picture of memory, additional studies from a variety of disciplines are needed. We believe that revealing memory will give us an insight on human life. These discoveries might also help elucidate memory-related diseases such as Alzheimer's and dementia. A better understanding of such diseases will eventually contribute to improved bioengineered therapeutics.
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