International Symposium Of Humanity, Society, Sports Sciences
Experimentally Alcoholic, Liver Damage Models;
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Plant Biochemistry
Gġrġġ is one of the most important ways of learning for people throughout history, the method of trial error.But at the point where science comes today, planned scratches ghettoed according to a hypothesis are the most important evidence-based tool in obtaining information.These types of quantitative array are divided into three observational, methodological and experimental types.Experimental landings are divided into intervention experiments and animal experiments.In experimental landscapes, the first agyam is usually performed by animal experiments.Animal experiments are widely used, especially in toxicity dishes and in biomedical traits aimed at the treatment of human diseases.There are ethical rules that must be followed as well as in experimental animals.The ethical principles can be explained by the "3r" rule set out by zoologist William Russell and microbiologist Rex L. Burch as short as possible: the use of the minimum possible number of animals, the provision of animal well-being and, if possible, the non-use of spinal animals.In this context, it is necessary to plan properly.In the models that are to be used in toxicity and/or disease patterns, the material methods of the patterns in literature are taken into account to ensure the use of a small number of animals and the well-being of animals.Alcohol is a hepatotoxine associated with the spectrum that varies from simple steatosis or fatty liver to severe liver damage such as alcoholic hepatitis, fibrosis and sirosis (1) and excess alcohol consumption is the main cause of liver-related deaths in Western countries (2).The effects on health of alcohol consumption varies according to the consumption order (absorption or non-absorption, acute or chronic) (3) are in the literature in which multiple factors (gender, obesity and genetics) are included in the progress of alcoholic liver disease (akh).Although more than 90 per cent of the incidents of serious alcohol consumption show fat accumulation, only 30 per cent of alcoholics have been to develop serious shapes (4).A major social health problem in this disease is tested various treatments for the prevention, reduction of damage and relief of sirosis.Animal experiments are carried out before humans are carried out for alcoholic liver disease, and there are many different types of animals applied in literature, doses applied and time of application.In this article, we experimentally reviewed the models of alcoholic liver damage, aiming to be the source of future arithmetics.Chronologically, literature assessment was made in a drawing of casey and ark published in 1985.Men weighing 275-300 grams of alcoholic liver damage are winstar rats.The application dose of ethanol is bound by 10g/kg/day and gradually increased by 16g/kg/day, which is the maximum dose of ethanol in 8-10 days.ġntragastic application of ethanol is in the histopathological examination of the liver of the rat and inflammation (5).In 2005 pushpakiran and ark.In their publications, the male winstar rat weighs 170-190 grams 2 times a day, 3 grams/kg of ethanol are applied with oral gathering.In the liver of the wheat who are sacrificed after 28 days of application, histopathologically sinusoidal dilatation, micro and macrovezic type of fatty variability, the presence of inflammatory cells in the portal area are indicated (6).
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